The phrase can be used: 1. to express extreme frustration; 2. in complete sarcasm to another who may be of general inconvenience to you; 3. with supreme elation or joyfulness, contradicting its meaning in a symphony of ironic vulgarity.
It can be used by either gender, despite its reference to the clitoris.
Expressing extreme frustration:
“Shit on my clit!”
“Yeah, asshole, keep shittin’ on my clit.”